2 Stellenangebote für Promoter (m/w/d) in Nordrhein-Westfalen

Postdoc – Protein homeostasis in mammalian oocytes (f/m/x) Group Gabriele Zaffagnini | CECAD Research Center We are one of the largest and oldest universities in Europe and one of the most important employers in our region. Our broad range of subjects, the dynamic development of our main research areas and our central location in Cologne make us attractive for students and researchers from around the world. We offer a wide range of career opportunities in science, technology, and administration. The ProteOOstasis Lab is a recently established research group at CECAD, located on one of Europe‘s top research campuses with state-of-the-art facilities. We focus on protein homeostasis in mammalian oocytes and its demise during reproductive aging. We are looking for an enthusiastic postdoc with a background in proteostasis, lysosomal signalling, and/or protein biochemistry. We offer a diverse range of research projects at the intersection between biochemistry, cell, and molecular biology, and an interdisciplinary range of experimental systems, from in vitro reconstitutions to live oocyte imaging. Candidates are welcome to propose additional projects within the scope and expertise of the lab. YOUR TASKS Dissect the regulation of endolysosomal super-organelles in mouse oocytes and its demise during reproductive aging Perform isolation, microinjection, immunostaining and imaging of mouse oocytes and embryos Optimise ultra-low-input proteomics and lipidomics for mouse oocytes Develop your own research project under the project in autonomy under the supervision of the PI Supervise undergraduate students and share your knowledge and expertise Promote a culture of respect, collaboration and mutual support in the lab YOUR PROFILE You hold a PhD in Biology, Biochemistry or similar field You have a proven record of research excellence, such as such as being a co- or first author of a publication (co-)first-author paper You are a team player who thrives in a collaborative working environment You have excellent written and oral English skills You are willing to work with mice. Previous accreditation as animal experimenter is desirable but not required You have a background in proteostasis, endolysosomal trafficking/signalling, biomolecular condensates and/or protein biochemistry Previous experience with oocyte/embryo manipulation, imaging, image analysis, and/or in vitro reconstituted systems is an advantage WE OFFER A large, international, top European research campus with state-of-the-art facilities An enthusiastic, collaborative, and curiosity-driven research environment A diverse working environment with equal opportunities Support in balancing work and family life Extensive advanced training opportunities Occupational health management offers Flexible working time models Opportunity to work remotely The University of Cologne promotes equal opportunities and diversity. Women will be considered preferentially in accordance with the Equal Opportunities Act of North Rhine-Westphalia (Landesgleichstellungsgesetz – LGG NRW). We also expressly welcome applications from all suitable candidates regardless of their gender, nationality, ethnic and social origin, religion, disability, age, sexual orientation and identity. The position is available from 1 January 2025 on a full-time basis (39,83 hours per week). The position is for two years with an option to extend up to 5 years (in total). If the applicant meets the relevant wage requirements and personal qualifications, the salary is based on remuneration group 13 TV-L of the pay scale for the German public sector. Please apply online with proof of the required qualifications without a photo under: https://jobportal.uni-koeln.de. The reference number is Wiss2409-06. The application deadline is 1 December 2024. For further inquiries, please contact Dr Gabriele Zaffagnini (gabriele.zaffagnini@uni-koeln.de).

PhD position (f/m/x) CRC 1218 on „mitochondrial regulation of cellular function“ We are one of the largest and oldest universities in Europe and one of the most important employers in our region. Our broad range of subjects, the dynamic development of our main research areas and our central location in Cologne make us attractive for students and researchers from around the world. We offer a wide range of career opportunities in science, technology, and administration. In the framework of the Collaborative Research Centre (CRC) 1218 on “Mitochondrial regulation of cellular function” (www.sfb1218.uni-koeln.de), scientists from different research institutions in Cologne have teamed up to study how mitochondria influence activity, differentiation and survival of the cell. The CRC1218 has been funded by the German Research Foundation (DFG) since July 2016. The Riemer lab (http://riemerlab.uni-koeln.de/) – part of the CRC1218 and located at the University of Cologne‘s Institute for Biochemistry – is looking for a doctoral student. Research in the Riemer laboratory focuses on different aspects of redox and mitochondrial biology. For example, we characterize the mechanisms of disulphide formation and hydrogen peroxide signalling in different cellular com¬partments. We are also interested in the physiological impacts of these processes for example in calcium and in metabolic signalling (Petrungaro et al, Cell Metabolism, 2015; Habich et al, Cell Reports, 2019; Calabrese et al, EMBO J, 2019 and Höhne et al, EMBO J, 2022). YOUR TASKS The doctoral candidate will perform a wide variety of biochemical and cell biological experiments including unbiased omics experiments and approaches with genetically encoded fluorescent proteins to uncover molecular mechanisms underlying different aspects of redox signalling from and in mammalian mitochondria. YOUR PROFILE We are looking for a doctoral candidate with a background in molecular biology, biochemistry, molecular medicine or biological chemistry. A Master‘s thesis on a topic related to the molecular mechanisms of cellular processes would be an advantage. Ability to plan experiments, develop methods, carry out analyses and summarize results in English is a requirement WE OFFER The doctoral candidate can build on the complementary expertise present in the CRC1218, .the excellent, state-of-the-art core facilities and the thriving, highly interactive scientific community in Cologne The candidate will expand his*her scientific horizon through participation in an interactive tailor-made educational program, the mito-RTG, that covers broad principles, and specific scientific and career development needs A diverse working environment with equal opportunities Support in balancing work and family life Extensive advanced training opportunities Occupational health management offers Flexible working time models The University of Cologne promotes equal opportunities and diversity. Women will be considered preferentially in accordance with the Equal Opportunities Act of North Rhine-Westphalia (Landesgleichstellungsgesetz – LGG NRW). We also expressly welcome applications from all suitable candidates regardless of their gender, nationality, ethnic and social origin, religion, disability, age, sexual orientation and identity. The position is available from 1 January 2025 on a part-time basis (25,89 hours per week).The position is to be filled for a fixed term of up to 2 years. An extension of the contract is possible. If the applicant meets the relevant wage requirements and personal qualifications, the salary is based on remuneration group 13 TV-L of the pay scale for the German public sector. Please apply online with proof of the required qualifications without a photo under: jan.riemer@uni-koeln.de The reference number is Wiss2409-08. The application deadline is 31 October 2024. For further inquiries, please contact Professor Dr Jan Riemer (jan.riemer@uni-koeln.de).